E3 ubiquitin-protein ligase TTC3; protein DCRR1; RING finger protein 105; TPR repeat protein D; tetratricopeptide repeat protein 3; TPR repeat protein 3 (TTC3, DCRR1, RNF105, TPRD)

Function

• E3 ubiquitin-protein ligase that mediates ubiquitination & subsequent degradation of phosphorylated Akt (AKT1, AKT2 & AKT3) in the nucleus
• acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation
• catalyzes the formation of Lys-48-polyubiquitin chains
• may play a role in neuronal differentiation
• inhibition via its interaction with CIT
• protein modification; protein ubiquitination
• phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity
• interacts (when phosphorylated on Ser-378) with AKT1, AKT2 & AKT3 (when phosphorylated)
• interacts with CIT

Structure

• contains 1 RING-type Zn+2 finger
• contains 4 TPR repeats

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

found in all tissues examined

More general terms

• tetratricopeptide repeat protein
• zinc finger protein
• E3 ubiquitin ligase
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7267
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7267
• OMIM: https://mirror.omim.org/entry/602259
• UniProt: http://www.uniprot.org/uniprot/P53804.html