rac-beta serine/threonine kinase (AKT2 kinase, protein kinase B-beta, PKB beta, AKT2)

Function

• general protein kinase capable of phosphorylating several known proteins
• 2 specific sites, one in the kinase domain (Thr-309) & the other in the C-terminal regulatory region (Ser-474), need to be phosphorylated for its full activation

Structure

• belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family, RAC subfamily
• contains 1 AGC-kinase C-terminal domain
• contains 1 PH domain
• contains 1 protein kinase domain

Expression

• expressed in all human cell types so far analyzed
• highly expressed in insulin responsive tissues

Pathology

• alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas
• mutation associated with severe insulin resistance & diabetes mellitus in one family

More general terms

• rac S/T kinase; AKT kinase

Database

• UniProt: http://www.uniprot.org/uniprot/P31751.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:208
• OMIM: https://mirror.omim.org/entry/164731
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=208