citron Rho-interacting kinase; CRIK; serine/threonine protein kinase 21 (CIT, KIAA0949, STK21)

Function

• required for KIF14 localization to the central spindle & midbody
• may play a role in cytokinesis
• RHO/RAC effector that binds to the GTP-bound forms of RHO & RAC1
• probably binds p21 with a tighter specificity in vivo
• dual specificity protein kinase activity catalyzing autophosphorylation & phosphorylation of exogenous substrates on both Ser/Thr & Tyr
• role in regulation of cytokinesis & in development of the central nervous system (putative)
• directly interacts with KIF14 (stronger interaction with the kinase-inactive form)
• homodimer (putative)
• interacts with TTC3

Structure

• belongs to the protein kinase superfamily, AGC Ser/Thr
• protein kinase family
• contains 1 AGC-kinase C-terminal domain
• contains 1 CNH domain
• contains 1 PH domain
• contains 1 phorbol-ester/DAG-type Zn+2 finger
• contains 1 protein kinase domain

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=3

More general terms

• serine/threonine kinase
• zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11113
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11113
• OMIM: https://mirror.omim.org/entry/605629
• UniProt: http://www.uniprot.org/uniprot/O14578.html