E3 ubiquitin-protein ligase RNF167 (RING finger protein 167, RING105, RNF167)

Function

• E3 ubiquitin-protein ligase (putative)
  • auto-ubiquitinated in vitro in the presence of UBE2D1 & UBE2E1
• growth regulation involved in G1/S transition
• ubiquitin conjugation, 3rd step
• interacts with SLC22A18

Structure

• contains 1 PA domain (protease associated domain)
• contains 1 RING-type zinc finger

Compartment

membrane, cytoplasmic membrane

Expression

expressed in kidney, liver

More general terms

• E3 ubiquitin ligase
• ring finger protein
• glycoprotein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H6Y7.html