ubiquitin-conjugating enzyme E2 E1; UbcH6; ubiquitin carrier protein E1; ubiquitin-protein ligase E1 (UBE2E1, UBCH6)

Function

• accepts ubiquitin from the E1 complex & catalyzes its covalent attachment to other proteins
• catalyzes covalent attachment of ISG15 to other proteins
• mediates selective degradation of short-lived & abnormal proteins
• in vitro catalyzes Lys-48-linked polyubiquitination
• protein modification; protein ubiquitination
• ISGylation suppresses ubiquitin E2 enzyme activity
• interacts with RNF14

Structure

• belongs to the ubiquitin-conjugating enzyme family

Compartment

nucleus

More general terms

• ubiquitin-conjugating protein E2 (ubiquitin carrier protein)
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7324
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7324
• OMIM: https://mirror.omim.org/entry/602916
• UniProt: http://www.uniprot.org/uniprot/P51965.html