RING finger protein 14; E3 ubiquitin-protein ligase RNF14; androgen receptor-associated protein 54; HFB30; triad2 protein (RNF14, ARA54, HRIHFB2038)

Function

• may play role as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes & transfers it to substrates, perhaps nuclear proteins
• may play role as a coactivator for androgen- &, to a lesser extent, progesterone-dependent transcription
• protein modification; protein ubiquitination
• RING-type Zn+2 finger-dependent & UBE2E2-dependent autoubiquitination
• interacts with the ubiquitin-conjugating enzymes UBE2E1 & UBE2E2
• interacts with AR/androgen receptor
  • testosterone- & RNF6-regulated
  • promotes AR transcriptional activity

Structure

• the N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway (putative)
• the RING-type Zn+2 finger is essential for the interaction with UBE2E2
• belongs to the RBR family, RNF14 subfamily
• contains 1 IBR-type Zn+2 finger
• contains 2 RING-type Zn+2 fingers
• contains 1 RWD domain
• lacks His in the RING-type domain 2, one of the conserved features of the family

Compartment

cytoplasm. nucleus

Expression

widely expressed

More general terms

• ring finger protein
• E3 ubiquitin ligase
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9604
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9604
• OMIM: https://mirror.omim.org/entry/605675
• UniProt: http://www.uniprot.org/uniprot/Q9UBS8.html