solute carrier family 22 member 18 (SLC22A18, organic cation transporter-like protein 2, imprinted multi-membrane spanning polyspecific transporter-related protein 1, efflux transporter-like protein, tumor-suppressing subchromosomal transferable fragment candidate gene protein 5, tumor-suppressing STF cDNA 5 protein, Beckwith-Wiedemann syndrome chromosome region 1 candidate protein A, p45-Beckwith-Wiedemann region 1 A, p45-BWR1A, solute carrier family 22 member 1-like, BWR1A, BWSCR1A, HET, IMPT1, ITM, ORCTL2, SLC22A1L, TSSC5)

Function

• transporter of organic cations via proton efflux antiport (putative)
• role in transport of chloroquine & quinidine-related compounds in kidney (putative)
• interacts with RNF167

Structure

• belongs to the major facilitator superfamily, organic cation transporter family

Compartment

• apical cell membrane
• localized at the apical membrane surface of renal proximal tubules

Expression

• expressed in adult & fetal kidney & liver,& adult colon > heart, brain & lung
• expressed in fetal renal proximal tubules (at protein level)

Pathology

• defects in SLC22A18 are associated with
  • breast cancer
  • lung cancer
• defects in SLC22A18 are the cause of rhabdomyosarcoma type 1

More general terms

• solute carrier family 22 (SLC22, SLC22A)
• transmembrane 8 protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5002
• OMIM: https://mirror.omim.org/entry/114480
• OMIM: https://mirror.omim.org/entry/211980
• OMIM: https://mirror.omim.org/entry/268210
• OMIM: https://mirror.omim.org/entry/602631
• UniProt: http://www.uniprot.org/uniprot/Q96BI1.html