E3 ubiquitin-protein ligase HERC4 (HECT domain & RCC1-like domain-containing protein 4, HERC4, KIAA1593)

Function

• E3 ubiquitin-protein ligase
• ubiquitin conjugation, 3rd step

Structure

• contains 1 HECT domain (E6AP-type E3 ubiquitin-protein ligase domain)
• contains 7 RCC1 repeats

Compartment

cytoplasm, cytosol

Alternative splicing

named isoforms=6

Expression

• expressed in brain & testis
• detected in heart, placenta
• expressed in fetal brain

More general terms

• E3 ubiquitin ligase

Database

• UniProt: http://www.uniprot.org/uniprot/Q5GLZ8.html