autocrine motility factor receptor (AMF receptor, gp78, AMFR)

Function

• specific receptor for the autocrine motility factor
• ubiquitin ligase activity
  • can target both itself & other proteins, including CD3D & APOB for proteasomal degradation
• component of complex required to couple retrotransloaction, ubiquitination, deglycosylation & proteasome-mediated degradation of misfolded proteins (NGLY1-SAKS1-AMFR-VCP-RAD23B complex, composed of NGLY1, SAKS1, AMFR, VCP & RAD23B)
• role in ubiquitin-proteasome systems
• interacts with UBE2G2/UBC7 through a region distinct from the RING finger

Structure

• contains 1 CUE domain
• contains 1 RING-type zinc finger

Compartment

endoplasmic reticulum membrane

Alternative splicing

named isoforms=2

Pathology

• mediates tumor invasion & metastasis

More general terms

• ring finger protein
• E3 ubiquitin ligase
• receptor
• transmembrane 7 protein

Component of

• NGLY1-SAKS1-AMFR-VCP-RAD23B complex

Database

• OMIM: https://mirror.omim.org/entry/603243
• UniProt: http://www.uniprot.org/uniprot/Q9UKV5.html