SAPK substrate protein 1; UBA/UBX 33.3 kDa protein (SAKS1, UBXN1)

Function

• component of a NGLY1/SAKS1/AMFR/VCP/RAD23B complex
• role in ubiquitin-proteasome systems
• interacts with HOMER2
• interacts directly with VCP
• binds polyubiquitin

Structure

• contains 1 UBA domain
• contains 1 UBX domain

Compartment

cytoplasm

Alternative splicing

named isoforms=2

More general terms

• phosphoprotein

Component of

• NGLY1-SAKS1-AMFR-VCP-RAD23B complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q04323.html