UV excision repair protein RAD23 homolog B; HR23B; hHR23B; XP-C repair-complementing complex 58 kD protein; p58 (RAD23B)

Function

• plays a central role both in proteosomal degradation of misfolded proteins & DNA repair.
• central component of a complex required to couple deglycosylation & proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol
• involved in DNA excision repair by stabilizing XPC protein
• may play a part in DNA damage recognition &/or in altering chromatin structure to allow access by damage-processing enzymes
• component of a complex required to couple retrotranslocation, ubiquitination & deglycosylation composed of NGLY1, SAKS1, AMFR, VCP & RAD23B (putative)
• interacts with the 26S proteasome
• interacts directly with NGLY1
• heterodimer of a 125 kD subunit (p125) & of a 58 kD subunit (p58)
• interacts with MJD & XPC

Structure

• the ubiquitin-like domain mediates interaction with MJD
• belongs to the RAD23 family
• contains 1 STI1 domain
• contains 2 UBA domains
• contains 1 ubiquitin-like domain

Compartment

nucleus. cytoplasm (putative)

More general terms

• rad23 homolog
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5887
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5887
• OMIM: https://mirror.omim.org/entry/600062
• UniProt: http://www.uniprot.org/uniprot/P54727.html