DNA repair protein complementing XP-C cells; xeroderma pigmentosum group C-complementing protein; p125 (XPC, XPCC)
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Function
- required for nucleotide excision repair
- may play a part in DNA damage recognition &/or in altering chromatin structure to allow access by damage-processing enzymes
- subunit of a heterodimeric protein that binds strongly to single-stranded DNA[2]
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with CETN2
Structure
belongs to the XPC family
Compartment
nucleus (probable)
Pathology
- defects in XPC are a cause of xeroderma pigmentosum complementation group C
Comparative biology
More general terms
References
- ↑ Bootsma D & Hoeijmakers JH DNA repair. Engagement with transcription. Nature 363:114 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8483493
- ↑ 2.0 2.1 Lehmann AR. Nucleotide excision repair and the link with transcription. Trends Biochem Sci. 1995 Oct;20(10):402-5. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8533152
- ↑ UniProt http://www.uniprot.org/uniprot/Q01831.html
- ↑ Allelic variations of the XP genes http://www.xpmutations.org/
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/XPCID122.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=XPC
- ↑ NIEHS-SNPs http://egp.gs.washington.edu/data/xpc/