centrin-2; caltractin isoform 1 (CETN2 CALT CEN2)

Function

• role in microtubule-organizing center structure & function
• required for centriole duplication & correct spindle formation
• role in regulating cytokinesis & genome stability via cooperation with CALM1 & CEP110
• binds 2 Ca+2

Structure

• monomer
• interacts with CEP110, SFI1 & with XPC
• belongs to the centrin family
• contains 4 EF-hand domains

Compartment

• centrosome, centriole
• centrosome of S-phase, interphase & mitotic cells

More general terms

• caltractin or centrin

Database

• UniProt: http://www.uniprot.org/uniprot/P41208.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1069
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1069
• OMIM: https://mirror.omim.org/entry/300006