ubiquitin-conjugating enzyme E2 G1; E217K; UBC7; ubiquitin carrier protein G1; ubiquitin-protein ligase G1 (UBE2G1, UBE2G)

Function

• accepts ubiquitin from the E1 complex & catalyzes its covalent attachment to other proteins
• in vitro catalyzes Lys-48-, as well as Lys-63-linked polyubiquitination
• may be involved in degradation of muscle-specific proteins
• mediates polyubiquitination of CYP3A4
• protein modification; protein ubiquitination

Structure

• belongs to the ubiquitin-conjugating enzyme family

Expression

• widely expressed
• expessed mainly in skeletal muscle

More general terms

• ubiquitin-conjugating protein E2 (ubiquitin carrier protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7326
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7326
• OMIM: https://mirror.omim.org/entry/601569
• UniProt: http://www.uniprot.org/uniprot/P62253.html