RING finger protein 12; E3 ubiquitin-protein ligase RLIM; LIM domain-interacting RING finger protein; RING finger LIM domain-binding protein; R-LIM; renal carcinoma antigen NY-REN-43 (RLIM, RNF12)

Function

• E3 ubiquitin-protein ligase
• acts as a negative coregulator for LIM homeodomain transcription factors by mediating ubiquitination & subsequent degradation of LIM cofactors LDB1 & LDB2 & by mediating recruitment of SIN3a/histone deacetylase corepressor complex
• ubiquitination & degradation of LIM cofactors LDB1 & LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM
• role in telomere length-mediated growth suppression by mediating ubiquitination & degradation of TERF1
• acts as an activator of random inactivation of X chromosome in the embryo
• protein modification; protein ubiquitination
• interacts with LIM/homeobox factors such as LHX3
• interacts with LDB1, LDB2 & SIN3A (putative)
• interacts with LIMK1 (putative)
• interacts (via N-terminus) with TERF1
• interacts (via C-terminus) with ESR1

Structure

• belongs to the RNF12 family
• contains 1 RING-type Zn+2 finger

Compartment

nucleus

Expression

expressed in many tissues

Pathology

• acts as a positive coregulator of ESR1-mediated transcription in breast cancer cells

More general terms

• ring finger protein
• E3 ubiquitin ligase
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51132
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51132
• OMIM: https://mirror.omim.org/entry/300379
• UniProt: http://www.uniprot.org/uniprot/Q9NVW2.html