LIM/homeodomain protein LHX3; LIM homeobox protein 3 (LHX3)

Function

• binds to & activates promoter of the alpha-glycoprotein gene
• synergistically enhances transcription from the prolactin promoter in cooperation with pit-1 (putative)

Structure

• contains 1 homeobox DNA-binding domain
• contains 2 LIM Zn+2-binding domains

Compartment

nucleus (probable)

Alternative splicing

• named isoforms=2
• additional isoforms seem to exist

Pathology

• defects in LHX3 are a cause of combined pituitary hormone deficiency

More general terms

• LIM/homeodomain protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8022
• OMIM: https://mirror.omim.org/entry/262600
• OMIM: https://mirror.omim.org/entry/600577
• UniProt: http://www.uniprot.org/uniprot/Q9UBR4.html