ubiquitin ligase protein MIB2; mind bomb homolog 2; zinc finger ZZ type with ankyrin repeat domain protein 1; skeletrophin; novelzin; novel zinc finger protein; NF-kappa-B-activating protein 002N (MIB2, DIP1, KIAA1323, ZZANK2)

Function

• mediates ubiquitination of delta proteins
• regulates delta1-mediated Notch signaling by ubiquitinating the intracellular domain of delta1, leading endocytosis
• ubiquitin conjugation, 3rd step
• ubiquitinated

Compartment

• cytoplasm
• localizes with endosomal compartment

Alternative splicing

named isoforms=6

Expression

• expressed in skeletal muscle > heart, brain, kidney

Pathology

• down-regulated in many primary skin melanomas
• down-regulation may result from methylation of gene

More general terms

• E3 ubiquitin ligase
• ankyrin repeat domain protein (ANKRD)

Database

• UniProt: http://www.uniprot.org/uniprot/Q96AX9.html