delta-like protein 1; Drosophila delta homolog 1; delta1; H-delta-1 (DLL1)

Introduction

similar to Drosophila delta protein

Function

• ligand for Notch receptors
• blocks differentiation of progenitor cells into B-cell lineage
• promotes differentiation or precursors into T-cell/NK-cell
• interacts with Notch receptors
• ubiquitinated by MIB1, MIB2, leading to endocytosis & degradation

Structure

• contains 1 DSL domain
• contains 8 EGF-like domains

Compartment

• membrane; single-pass type 1 membrane protein

Expression

• expressed in heart, pancreas > brain, muscle >> placenta, lung, liver, kidney

More general terms

• delta homolog protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=28514
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:28514
• OMIM: https://mirror.omim.org/entry/606582
• UniProt: http://www.uniprot.org/uniprot/O00548.html