ubiquitin ligase protein MIB1; mind bomb homolog 1; DAPK-interacting protein 1; DIP-1; zinc finger ZZ type with ankyrin repeat domain protein 2 (MIB1, DIP1, KIAA1323, ZZANK2)

Function

• mediates ubiquitination of delta proteins
• regulates delta1-mediated Notch signaling by ubiquitinating the intracellular domain of delta1, leading endocytosis
• mediates ubiquitination & subsequent proteasomal degradation of DAPK1
  • antagonizes anti-apoptotic effects of DAPK1
  • promotes TNF-induced apoptosis
• ubiquitin conjugation, 3rd step

Compartment

cytoplasm, localizes to the plasma membrane

Expression

• widely expressed at low level
• ubiquitinated

Pathology

• in epilepsy brain tissue, levels of expression are increased in cytoplasm & endoplasmic reticulum

More general terms

• E3 ubiquitin ligase
• ankyrin repeat domain protein (ANKRD)

Database

• OMIM: https://mirror.omim.org/entry/608677
• UniProt: http://www.uniprot.org/uniprot/Q86YT6.html