E3 ubiquitin-protein ligase TRIM13; B-cell chronic lymphocytic leukemia tumor suppressor Leu5; Leukemia-associated protein 5; tumor suppressor RFP2; RING finger protein 77; Ret finger protein 2; tripartite motif-containing protein 13 (TRIM13, LEU5, RFP2, RNF77)

Function

• E3 ubiquitin ligase
• role in retrotranslocation & turnover of membrane & secretory proteins from the endoplasmic retuculum (ER) through the unfolded protein response (ERAD)
• protein modification; protein ubiquitination
• auto-ubiquitinated; which leads to proteasomal degradation
• interacts (via C-terminal domain) with VCP

Structure

• the RING-type Zn+2 finger is required for auto- polyubiquitination
• the C-terminal domain transmembrane domain is required for localization to the ER
• belongs to the TRIM/RBCC family
• contains 1 B box-type Zn+2 finger
• contains 1 RING-type Zn+2 finger

Compartment

• endoplasmic reticulum membrane

Alternative splicing

named isoforms=3

Genetics

• located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia

More general terms

• anti-oncoprotein (tumor suppressor protein)
• tripartite motif-containing protein (trim protein)
• E3 ubiquitin ligase
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10206
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10206
• OMIM: https://mirror.omim.org/entry/605661
• UniProt: http://www.uniprot.org/uniprot/O60858.html