E3 ubiquitin-protein ligase Hakai (Casitas B-lineage lymphoma transforming sequence-like protein 1, c-Cbl-like protein 1, RING finger protein 188, CBLL1, HAKAI, RNF188)

Function

• promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis & degradation
• ubiquitin conjugation, 3rd step
• interacts with tyrosine-phosphorylated CDH1

Structure

• contains 1 C2H2-type zinc finger
• contains 1 RING-type zinc finger

More general terms

• ring finger protein
• C2H2 type zinc finger protein
• E3 ubiquitin ligase

Database

• OMIM: https://mirror.omim.org/entry/606872
• UniProt: http://www.uniprot.org/uniprot/Q75N03.html