E3 ubiquitin-protein ligase RNF144A; RING finger protein 144A; ubiquitin-conjugating enzyme 7-interacting protein 4; UbcM4-interacting protein 4 (RNF144A, KIAA0161, RNF144, UBCE7IP4)

Function

• E3 ubiquitin-protein ligase that accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 & UBE2L6 in the form of a thioester & then directly transfers the ubiquitin to targeted substrates (putative)
• protein modification; protein ubiquitination
• interacts with UBE2L3

Structure

• belongs to the RBR family, RNF144 subfamily
• contains 1 IBR-type Zn+2 finger
• contains 2 RING-type Zn+2 fingers
• lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family

Compartment

• membrane (potential)

More general terms

• ubiquitin conjugating enzyme 7 interacting protein
• ring finger protein
• E3 ubiquitin ligase
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9781
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9781
• UniProt: http://www.uniprot.org/uniprot/P50876.html