E3 ubiquitin-protein ligase ZNRF1 (zinc/RING finger protein 1, nerve injury-induced gene 283 protein, ZNRF1, NIN283)

Function

• E3 ubiquitin-protein ligase
• role in establisment & maintenance of neuronal transmission & plasticity via its ubiquitin-protein ligase activity
• ubiquitin conjugation, 3rd step

Structure

• contains 1 RING-type zinc finger, required for E3 ligase activity

Compartment

• endosome, lysosome, peripheral membrane
• associated with synaptic vesicle membranes in neurons

Alternative splicing

named isoforms=2

Expression

• expressed primarily in the nervous system
• expression higher in developing brain relative to adult
• expressed at low levels in testis & thymus

More general terms

• E3 ubiquitin ligase
• ring finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8ND25.html