E3 ubiquitin-protein ligase CCNB1IP1; cyclin-B1-interacting protein 1; human enhancer of invasion 10; E3 ubiquitin-protein ligase HEI10 (CCNB1IP1, C14orf18, HEI10)

Function

• E3 ubiquitin-protein ligase
• modulates cyclin B levels & participates in the regulation of cell cycle progression through the G2 phase
• overexpression causes delayed entry into mitosis
• protein modification; protein ubiquitination
• ubiquitinated; autoubiquitinated
• phosphorylated by CDK1 on Ser or Thr (in vitro)
• binds CCNB1 & UBE2L3

Structure

contains 1 RING-type Zn+2 finger

Compartment

• nucleus, chromosome
• may associate with segregating chromosomes during metaphase & anaphase

Expression

• expressed in heart > liver & kidney > placenta, brain & lung

More general terms

• E3 ubiquitin ligase
• nuclear protein
• ring finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57820
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57820
• OMIM: https://mirror.omim.org/entry/608249
• UniProt: http://www.uniprot.org/uniprot/Q9NPC3.html