E3 ubiquitin-protein ligase MARCH1 (membrane-associated RING finger protein 1, membrane-associated RING-CH protein 1, MARCH-1, RING finger protein 171, MARCH1, RNF171)

Function

• E3 ubiquitin-protein ligase
• ubiquitin conjugation, 3rd step
• may mediate ubiquitination of TFRC, CD86 & FAS, & promote their subsequent endocytosis & sorting to lysosomes via multivesicular bodies

Structure

• contains 1 RING-CH-type zinc finger, required for E3 ligase activity Compatment: cytoplasmic vesicle membrane

Alternative splicing

named isoforms=2

Expression

expressed in lymph nodes, spleen & lung

More general terms

• E3 ubiquitin ligase
• ring finger protein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8TCQ1.html