E3 ubiquitin-protein ligase HECW2 (HECT, C2 & WW domain-containing protein 2; NEDD4-like ubiquitin-protein ligase 2; HECW2; KIAA1301; NEDL2)

Function

• ubiquitin conjugation, 3rd step
• E3 ubiquitin-protein ligase
• mediates ubiquitination of TP73
• acts to stabilize TP73 & enhance activation of transcription by TP73

Structure

• contains 1 C2 domain
• contains 1 HECT domain (E6AP-type E3 ubiquitin-protein ligase)
• contains 2 WW domains

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• predominantly expressed in adult brain, lung, heart

More general terms

• E3 ubiquitin ligase

Database

• UniProt: http://www.uniprot.org/uniprot/Q9P2P5.html