tumor protein p73; p53-like transcription factor; p53-related protein (TP73, p73)

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Function

isoforms alpha & beta interact with HIPK2

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

Compartment

nucleus

Alternative splicing

Expression

Pathology

More general terms

More specific terms

References

  1. Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, Minty A, Chalon P, Lelias JM, Dumont X, Ferrara P, McKeon F, Caput D. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell. 1997 Aug 22;90(4):809-19. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9288759
  2. 2.0 2.1 Jost CA, Marin MC, Kaelin WG Jr. p73 is a simian [correction of human] p53-related protein that can induce apoptosis. Nature. 1997 Sep 11;389(6647):191-4. Erratum in: Nature 1999 Jun 24;399(6738):817. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9296498
  3. Irwin M, Marin MC, Phillips AC, Seelan RS, Smith DI, Liu W, Flores ER, Tsai KY, Jacks T, Vousden KH, Kaelin WG Jr. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature. 2000 Oct 5;407(6804):645-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11034215
  4. Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7161
  5. 5.0 5.1 George J Novel ALS Risk Gene Identified. Findings suggest apoptosis in motor neurons play an important role. MedPage Today June 17, 2021 https://www.medpagetoday.com/neurology/generalneurology/93170
    Russell KL et al Pathogenic effect of TP73 Gene Variants in People With Amyotrophic Lateral Sclerosis. Neurology 2021. June 16. PMID: https://www.ncbi.nlm.nih.gov/pubmed/34135078 https://n.neurology.org/content/early/2021/06/15/WNL.0000000000012285

Database