E3 ubiquitin-protein ligase KCMF1; K+ channel modulatory factor; PCMF; FGF-induced in gastric cancer; ZZ-type zinc finger-containing protein 1 (KCMF1, FIGC, ZZZ1)

Function

• intrinsic E3 ubiquitin ligase activity
• promotes ubiquitination

Structure

• belongs to the KCMF1 family
• contains 1 C2H2-type Zn+2 finger
• contains 1 ZZ-type Zn+2 finger

Expression

• spleen, small intestine, ovary, peripheral blood, lung, kidney & pancreas
• expressed at low levels in thymus, prostate, testis, colon, heart, brain, placenta & liver

Pathology

• up-regulated by basic fibroblast growth factor (bFGF) in gastric cancer cells

More general terms

• E3 ubiquitin ligase
• C2H2 type zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9P0J7.html