E3 ubiquitin-protein ligase TRIM37; tripartite motif-containing protein 37; mulibrey nanism protein (TRIM37, KIAA0898, MUL, POB1)

Function

• E3 ubiquitin-protein ligase
• protein modification; protein ubiquitination
• auto-ubiquitinated

Structure

• belongs to the TRIM/RBCC family
• contains 1 B box-type Zn+2 finger
• contains 1 MATH domain
• contains 1 RING-type Zn+2 finger

Compartment

• cytoplasm, perinuclear region. peroxisome
• found in vesicles of the peroxisome
• aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteosomal degradation

Alternative splicing

named isoforms=2

Expression

ubiquitous

Pathology

• defects in TRIM37 are the cause of mulibrey nanism

More general terms

• tripartite motif-containing protein (trim protein)
• E3 ubiquitin ligase
• phosphoprotein

Additional terms

• Mulibrey nanism (muscle-liver-brain-eye nanism, pericardial constriction & growth failure)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4591
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4591
• OMIM: https://mirror.omim.org/entry/253250
• OMIM: https://mirror.omim.org/entry/605073
• UniProt: http://www.uniprot.org/uniprot/O94972.html