E3 ubiquitin-protein ligase TRIM11; tripartite motif-containing protein 11; RING finger protein 92; protein BIA1 (TRIM11, RNF92)

Function

• may have E3 ubiquitin ligase activity
• may contribute to regulation of the intracellular level of humanin or humanin-containing proteins through the proteasomal degradation pathway
• protein modification; protein ubiquitination
• binds cytoplasmic tail of integrin alpha-1
• interacts with the humanin peptide (putative)

Structure

• the coiled-coil domain & the B30.2 domain are both necessary for interaction with humanin (putative)
• belongs to the TRIM/RBCC family
• contains 1 B box-type Zn+2 finger
• contains 1 B30.2/SPRY domain
• contains 1 RING-type Zn+2 finger

Compartment

cytoplasm, nucleus

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• tripartite motif-containing protein (trim protein)
• E3 ubiquitin ligase
• ring finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=81559
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:81559
• OMIM: https://mirror.omim.org/entry/607868
• UniProt: http://www.uniprot.org/uniprot/Q96F44.html