apoptosis-resistant E3 ubiquitin protein ligase 1 (AREL1, KIAA0317)

Function

• E3 ubiquitin-protein ligase
  • accepts ubiquitin froman E2 ubiquitin-conjugating enzyme in the form of a thioester & directly transfers the ubiquitin to targeted substrates
• inhibits apoptosis by ubiquitinating & targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 & SEPT4/ARTS which are released from mitochondrion into the cytosol following apoptotic
• stimulation

Structure

• contains 1 filamin repeat
• contains 1 HECT domain (E6AP-type E3 ubiquitin-protein ligase domain)

Compartment

• membrane (putative). cytoplasm, cytosol

Alternative splicing

named isoforms=2

More general terms

• E3 ubiquitin ligase
• membrane protein
• cytoskeletal protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9870
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9870
• OMIM: https://mirror.omim.org/entry/615380
• UniProt: http://www.uniprot.org/uniprot/O15033.html