E3 ubiquitin-protein ligase HACE1 (HECT domain & ankyrin repeat-containing E3 ubiquitin-protein ligase 1, HACE1, KIAA1320)

Function

• E3 ubiquitin-protein ligase
• role in cellular proteins degradation
• ubiquitin conjugation, 3rd step
• interacts with the 26S proteasomal complex through the 20S core proteasomal subunit

Structure

• contains 6 ANK repeats
• contains 1 HECT domain (E6AP-type E3 ubiquitin-protein ligase domain)

Compartment

• cytoplasm, endoplasmic reticulum
• significant portion localizes to the endoplasmic reticulum

Alternative splicing

named isoforms=3

Expression

• expressed in multiple tissues including heart, brain, kidney
• expressed in fetal & pediatric kidney cells

Pathology

• down-regulated in sporadic Wilms tumor

More general terms

• E3 ubiquitin ligase

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IYU2.html