E3 ubiquitin-protein ligase TRIP12; thyroid receptor-interacting protein 12; TR-interacting protein 12; TRIP-12 (TRIP12, KIAA0045)

Function

• component of PA700, an ATP-dependent multisubunit protein that activates the proteolytic activities of the multifunctional proteinase (20S proteasome) of the 26S complex
• specifically interacts with the ligand binding domain of the thyroid hormone receptor (thyroid hormone T3-independent) & with retinoid X receptor (RXR)
• could be E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester & then directly transfers the ubiquitin to targeted substrates
• a Cys is required for ubiquitin-thioester formation
• protein modification; protein ubiquitination
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the UPL family, K-HECT subfamily
• contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
• contains 1 WWE domain

More general terms

• protein subunit
• thyroid hormone receptor interacting protein (TRIP)
• E3 ubiquitin ligase
• phosphoprotein

Component of

• 19S proteasome (PA700 complex)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9320
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9320
• OMIM: https://mirror.omim.org/entry/604506
• UniProt: http://www.uniprot.org/uniprot/Q14669.html