zinc finger protein 645; E3 ubiquitin-protein ligase ZNF645 (ZNF645)

Function

• E3 ubiquitin ligase
• catalyzes covalent attachmentof ubiquitin moieties onto substrate proteins
• protein modification; protein ubiquitination

Structure

• contains 1 C2H2-type Zn+2 finger
• contains 1 RING-type Zn+2 finger

Compartment

• cytoplasm
• localized over the postacrosomal perinuclear theca region & the entire length of sperm tail

Expression

• exclusively expressed in testis & sperm, including spermatocytes, round & elongated spermatids, & Leydig cells

More general terms

• E3 ubiquitin ligase
• ring finger protein
• C2H2 type zinc finger protein
• testis-specific protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=158506
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:158506
• UniProt: http://www.uniprot.org/uniprot/Q8N7E2.html