E3 ubiquitin-protein ligase TRIM31; tripartite motif-containing protein 31 (TRIM31, C6orf13 RNF)

Function

• regulator of Src-induced anchorage independent cell growth (putative)
• may have E3 ubiquitin-protein ligase activity
• protein modification; protein ubiquitination
• auto-ubiquitinated (in vitro)
• interacts with isoform p52shc of SHC1 (putative)
• may form oligomers

Structure

• belongs to the TRIM/RBCC family
• contains 1 B box-type Zn+2 finger
• contains 1 RING-type Zn+2 finger

Compartment

• cytoplasm
• mitochondrion
• predominantly expressed in the cytoplasm

Alternative splicing

• named isoforms=2; alpha, beta
• at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Expression

Up-regulated in gastric adenocarcinomas

More general terms

• tripartite motif-containing protein (trim protein)
• E3 ubiquitin ligase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11074
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11074
• OMIM: https://mirror.omim.org/entry/609316
• UniProt: http://www.uniprot.org/uniprot/Q9BZY9.html