E3 ubiquitin-protein ligase BRE1A; BRE1-A; hBRE1; RING finger protein 20 (RNF20, BRE1A)

Function

• E3 ubiquitin ligase protein
  • ubiquitin conjugation, 3rd step
• monoubiquitination of Lys-120 of histone H2B
  • specific tag for epigenetic transcriptional activation
  • required for histone H3 Lys-4 & Lys-79 methylation
• forms a ubiquitin ligase complex in cooperation with E2 enzyme UBE2E1
• histone code & gene regulation
• transcriptional activation of Hox genes
• component of the RNF20/40 complex

Structure

homodimer

Compartment

nucleus

More general terms

• E3 ubiquitin ligase
• ring finger protein
• nuclear protein
• phosphoprotein

Component of

• BRE1A/BRE1B/UBE2E1 (RNF20/40) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56254
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56254
• OMIM: https://mirror.omim.org/entry/607699
• UniProt: http://www.uniprot.org/uniprot/Q5VTR2.html