UbcH10-binding protein with a HECT-like domain (UBE3D, C6orf157, H10BH)

Function

• E3 ubiquitin-protein ligase
• interacts with UBE2C/UbcH10
• in vitro, interacts with cyclin B
• protein degradation; protein ubiquitinylation
• ubiquitinated by UBCH10 (E2 ubiquitin-conjugating enzyme)

Structure

• C-terminal half (AA 188-389) is able to bind cyclin B & shows a self-ubiquitinylation activity (mono-, poly, or multi-ubiquitinylation, HECT-like sequence dependent)

Compartment

cytoplasm (putative)

More general terms

• E3 ubiquitin ligase

Database

• UniProt: http://www.uniprot.org/uniprot/Q7Z6J8.html