ubiquitin-conjugating enzyme E2 C; UbcH10; ubiquitin carrier protein C; ubiquitin-protein ligase C (UBE2C, UBCH10)

Function

• accepts ubiquitin from the E1 complex & catalyzes its covalent attachment to other proteins
• in vitro catalyzes Lys-11- & Lys-48-linked polyubiquitination
• essential factor of the anaphase promoting complex/cyclosome (APC/C)
• acts by initiating Lys-11-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome & promoting mitotic exit
• protein modification; protein ubiquitination
• autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome
• its degradation plays a central role in APC/C regulation, allowing cyclin-A accumulation before S phase entry
• APC/C substrates inhibit the autoubiquitination of UBE2C/UBCH10 but not its E2 function, hence APC/C remaining active until its substrates have been destroyed
• component of the APC/C complex

Structure

belongs to the ubiquitin-conjugating enzyme family

More general terms

• ubiquitin-conjugating protein E2 (ubiquitin carrier protein)

Component of

• anaphase promoting complex (APC, cyclosome)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11065
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11065
• OMIM: https://mirror.omim.org/entry/605574
• UniProt: http://www.uniprot.org/uniprot/O00762.html