RING finger protein 13; E3 ubiquitin-protein ligase RNF13 (RNF13 RZF)

Function

• E3 ubiquitin-protein ligase
• may play a role in controlling cell proliferation
• protein modification; protein ubiquitination
• auto-ubiquitinated

Structure

• the RING-type Zn+2 finger domain is required for E3 ligase activity
• contains 1 PA (protease associated) domain
• contains 1 RING-type Zn+2 finger

Compartment

• endoplasmic reticulum membrane
• Golgi membrane
• late endosome membrane
• lysosome membrane
• nuclear inner membrane (putative)
• under certain conditions, relocalizes to recycling endosomes & to the inner nuclear membrane
• single-pass membrane protein (putative)

Expression

• widely expressed (at protein level)
• in normal pancreas
  • expressed in islets of Langerhans
  • not expressed in pancreatic ducts
  • not expressed in pancreatic acini

More general terms

• ring finger protein
• E3 ubiquitin ligase
• phosphoprotein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11342
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11342
• OMIM: https://mirror.omim.org/entry/609247
• UniProt: http://www.uniprot.org/uniprot/O43567.html