E3 ubiquitin-protein ligase DZIP3; DAZ-interacting protein 3; RNA-binding ubiquitin ligase of 138 kDa; hRUL138 (DZIP3, KIAA0675)

Function

• E3 ubiquitin ligase protein
• mediates ubiquitination & subsequent proteasomal degradation of target proteins
• E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester & then directly transfer the ubiquitin to targeted substrates
• able to specifically bind RNA
• protein modification; protein ubiquitination
• interacts with DAZ proteins

Structure

contains 1 RING-type Zn+2 finger

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• widely expressed at low level
• highly expressed in skeletal muscle, kidney & heart
• expressed at low level in placenta, lung, brain, liver & pancreas

More general terms

• E3 ubiquitin ligase
• ring finger protein
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9666
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9666
• OMIM: https://mirror.omim.org/entry/608672
• UniProt: http://www.uniprot.org/uniprot/Q86Y13.html