zinc finger protein 364; E3 ubiquitin-protein ligase RNF115; RING finger protein 115; Rabring 7 (RNF115, ZNF364)

Function

• acts as an E2-dependent E3 ubiquitin-protein ligase
• may be involved in endocytic trafficking
• protein modification; protein ubiquitination
• RING-type Zn+2 finger-dependent & E2-dependent autoubiquitination
• interacts with RAB7A

Structure

contains 1 RING-type Zn+2 finger

Compartment

• cytoplasm (putative)
• the GTP-bound form of RAB7A recruits RNF115 from the cytoplasm into late endosomes/lysosomes (putative)

Expression

• expressed at extremely low levels in normal breast, prostate, lung, colon
• higher levels of expression are detected in heart, skeletal muscle, testis
• higher levels in breast cancer & prostate cancer cells

More general terms

• E3 ubiquitin ligase
• ring finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27246
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27246
• UniProt: http://www.uniprot.org/uniprot/Q9Y4L5.html