RING finger protein 34; E3 ubiquitin-protein ligase RNF34; caspase regulator CARP1; caspases-8 & -10-associated RING finger protein 1; CARP-1; FYVE-RING finger protein Momo; human RING finger homologous to inhibitor of apoptosis protein; hRFI; RING finger protein RIFF (RNF34)

Function

• E3 ubiquitin protein ligase activity
• regulates levels of CASP8 & CASP10 by targeting them for proteasomal degradation
• protects cells against apoptosis induced by TNF.
• binds phosphatidylinositol-5-phosphate & phosphatidylinositol-3-phosphate.
• interacts with DNAJA3 (putative), CASP8, CASP10
• auto-ubiquitinated (in vitro)
• proteolytically cleaved by caspases after induction of apoptosis by TNF

Structure

• contains 1 FYVE-type Zn+2 finger
• contains 1 RING-type Zn+2 finger
• contains 2 SAP domains

Compartment

• nucleus, nucleoplasm, nuclear speckle
• intracellular membrane, peripheral membrane

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• expressed in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon, leukocytes

Notes

• originally isolated as potential interaction partner of mitochondrial protein DNAJA3, but the 2 proteins are NOT in the same cellular compartments

More general terms

• ring finger protein
• E3 ubiquitin ligase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=80196
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:80196
• OMIM: https://mirror.omim.org/entry/608299
• UniProt: http://www.uniprot.org/uniprot/Q969K3.html