E3 ubiquitin-protein ligase MARCH11 (membrane-associated RING finger protein 11, MARCH-XI, MARCH11)

Function

• E3 ubiquitin-protein ligase
• mediates polyubiquitination of CD4
• may play a role in ubiquitin-dependent protein sorting in develomenting spermatids (putative)
• interacts (via YXXL motif) with AP1M1
• interacts (via PDZ-binding motif) with LIN7A
• interacts with unidentified fucose glycoproteins (putative)
• protein modification; protein ubiquitination

Structure

• the RING-CH-type Zn+2 finger domain is required for E3 ligase activity (putative)
• contains 1 RING-CH-type Zn+2 finger

Compartment

• cytoplasmic vesicle membrane

Alternative splicing

named isoforms=2

More general terms

• E3 ubiquitin ligase
• zinc finger protein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/A6NNE9.html