E3 ubiquitin-protein ligase rififylin (RING finger & FYVE-like domain-containing protein 1, FYVE-RING finger protein Sakura, Fring, caspases-8 & -10-associated RING finger protein 2, CARP-2, caspase regulator CARP2, RING finger protein 189, RING finger protein 34-like, RFFL, RNF189, RNF34L)
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Function
- E3 ubiquitin protein ligase activity
- regulates levels of CASP8 & CASP10 by targeting them for proteasomal degradation
- anti-apoptotic activity
- may bind phosphatidylinositol phosphates
- ubiquitin conjugation, 3rd step
- binds CASP8 & CASP10
- rapidly degraded after stimulation with TNFSF10, probably by caspases
- auto-ubiquitinated
Structure
- palmitoylated contains 1 FYVE-type zinc finger contains 1 RING-type zinc finger contains 2 SAP domains
Compartment
cytoplasm, peripheral membrane
Alternative splicing
named isoforms=3
Expression
- ubiquitous
- expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes