CD253; tumor necrosis factor ligand superfamily member 10; apo-2 ligand; apo-2L; TNF-related apoptosis-inducing ligand; protein TRAIL (TNFSF10, APO2L, TRAIL)

Function

• cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 & possibly also to TNFRSF11B/OPG
• induces apoptosis
• its activity may be modulated by binding to decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 & TNFRSF11B/OPG that cannot induce apoptosis

Cofactor: binds 1 Zn+2 per trimer

Structure

• homotrimer
• belongs to the tumor necrosis factor family

Compartment

• membrane; single-pass type 2 membrane protein (putative)

Expression

• widespread; most predominant in spleen, lung & prostate

More general terms

• tumor necrosis factor (TNF) family protein
• CD antigen

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8743
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8743
• OMIM: https://mirror.omim.org/entry/603598
• UniProt: http://www.uniprot.org/uniprot/P50591.html