tumor necrosis factor receptor superfamily member 11B; osteoprotegerin; osteoclastogenesis inhibitory factor (TNFRSF11B OCIF OPG)
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Function
- acts as decoy receptor for RANKL & thus neutralizes its function in osteoclastogenesis
- regulation of osteoclast activity
- inhibits activation of osteoclasts & promotes osteoclast apoptosis in vitro
- bone homeostasis seems to depend on the local RANKL/OPG ratio
- may also play a role in preventing arterial calcification
- may act as decoy receptor for TRAIL & protect against apoptosis
- TRAIL binding blocks the inhibition of osteoclastogenesis
Structure
- homodimer
- N-glycosylated
- contains sialic acid residues
- N-terminus is blocked
- contains 2 death domains
- contains 4 TNFR-Cys repeats
Compartment
Expression
- highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, & bone marrow
- detected at very low levels in brain, placenta & skeletal muscle
- highly expressed in fetal kidney, liver & lung
- up-regulated by increasing Ca+2-concentration in the medium & estrogens
- down-regulated by glucocorticoids
Pathology
- defects in TNFRSF11B are the cause of juvenile Paget's disease
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/O00300.html
- ↑ NIEHS-SNPs http://egp.gs.washington.edu/data/tnfrsf11b/
- ↑ Journal Watch vol 19, #24, pg 192-93 Dec 15, 1999
- ↑ Kong YY et al Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 402:304, 1999 PMID: https://www.ncbi.nlm.nih.gov/pubmed/10580503