tumor necrosis factor receptor superfamily member 10D; decoy receptor 2; DcR2; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL-R4; TRAIL receptor with a truncated death domain; CD264 (TNFRSF10D, DCR2, TRAILR4, TRUNDD, UNQ251/PRO288)

Function

• receptor for the cytotoxic ligand TRAIL

Structure

• contains a truncated death domain & hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis.
• contains 3 TNFR-Cys repeats

Compartment

membrane

Expression

• widely expressed
• expressed in fetal kidney, lung & liver, & in adult testis & liver
• also expressed in peripheral blood leukocytes, colon & small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta & heart

More general terms

• tumor necrosis factor [TNF] receptor family
• CD antigen

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8793
• OMIM: https://mirror.omim.org/entry/603614
• UniProt: http://www.uniprot.org/uniprot/Q9UBN6.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8793
• Kegg: http://www.genome.jp/dbget-bin/www_bget?