tumor necrosis factor receptor superfamily member 10B; death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD262 (TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9, UNQ160/PRO186)

^[1]^[2]^[3]^[4]

Function

receptor for the cytotoxic ligand TNFSF10/TRAIL
the adapter molecule FADD recruits caspase-8 to the activated receptor; the resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis
promotes the activation of NF- kappa-B
TRAILR1 & TRAILR2 mediate apoptosis
can interact with TRADD & RIP

membrane

named isoforms=2; TRICK2A, TRICK2B

widely expressed in adult & fetal tissues
highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach & throughout the intestinal tract;
not detectable in brain
induced by the tumor suppressor p53

very highly expressed in tumor cell lines such as HeLa S3, K562, HL-60, SW480, A549 & G361;
defects in TNFRSF10B may be a cause of squamous cell carcinoma of the head & neck

may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

↑ UniProt http://www.uniprot.org/uniprot/O14763.html
↑ Pan G et al An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277:815-8, 1997 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9242610
↑ Wu GS et al KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nature Genetics 17:141-3, 1997 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9326928
↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8795