tumor necrosis factor receptor superfamily member 10A; death receptor 4; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAIL-R1; CD261 (TNFRSF10A, APO2, DR4, TRAILR1)
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Function
- receptor for the cytotoxic ligand TNFSF10/TRAIL
- the adapter molecule FADD recruits caspase-8 to the activated receptor; the resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis
- TRAILR1 & TRAILR2 mediate apoptosis; TRAILR3 & TRAILR4 do not
- promotes the activation of NF-kappa-B
- can interact with TRADD & RIP
Structure
- contains 1 death domain
- contains 3 TNFR-Cys repeats
Compartment
membrane
Expression
- widely expressed
- high levels are found in spleen, peripheral blood leukocytes, small intestine & thymus
- also expressed in K562 erythroleukemia cells, MCF7 breast carcinoma cells & activated T-cells
Pathology
- plasma TNFRSF10A associated with loneliness[4]
More general terms
References
- ↑ OMIM https://mirror.omim.org/entry/603611
- ↑ UniProt http://www.uniprot.org/uniprot/O00220.html
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8797
- ↑ Jump up to: 4.0 4.1 Shen C, Zhang R, Yu J, Sahakian BJ, Cheng W, Feng J. Plasma proteomic signatures of social isolation and loneliness associated with morbidity and mortality. Nat Hum Behav. 2025 Jan 3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39753750