tumor necrosis factor receptor superfamily member 10A; death receptor 4; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAIL-R1; CD261 (TNFRSF10A, APO2, DR4, TRAILR1)

Function

• receptor for the cytotoxic ligand TNFSF10/TRAIL
• the adapter molecule FADD recruits caspase-8 to the activated receptor; the resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis
• TRAILR1 & TRAILR2 mediate apoptosis; TRAILR3 & TRAILR4 do not
• promotes the activation of NF-kappa-B
• can interact with TRADD & RIP

Structure

• contains 1 death domain
• contains 3 TNFR-Cys repeats

Compartment

membrane

Expression

• widely expressed
• high levels are found in spleen, peripheral blood leukocytes, small intestine & thymus
• also expressed in K562 erythroleukemia cells, MCF7 breast carcinoma cells & activated T-cells

More general terms

• tumor necrosis factor [TNF] receptor family
• phosphoprotein
• CD antigen
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8797
• OMIM: https://mirror.omim.org/entry/603611
• UniProt: http://www.uniprot.org/uniprot/O00220.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8797