tumor necrosis factor receptor superfamily member 10C; decoy receptor 1; DcR1; Decoy TRAIL receptor without death domain; TNF-related apoptosis-inducing ligand receptor 3; TRAIL receptor 3; TRAIL-R3; trail receptor without an intracellular domain; lymphocyte inhibitor of TRAIL; antagonist decoy receptor for TRAIL/apo-2L; CD263 (TNFRSF10C DCR1 LIT TRAILR3 TRID UNQ321/PRO366)

Function

• receptor for the cytotoxic ligand TRAIL
• may protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 & R2 for binding to the ligand

Structure

• N-glycosylated & O-glycosylated
• lacks a cytoplasmic death domain & thus is not capable of inducing apoptosis.
• contains 3 TNFR-cys repeats

Compartment

cell membrane; lipid-anchor, GPI-anchor

Expression

• higher expression in normal tissues than in tumor cell lines
• highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung & heart

More general terms

• tumor necrosis factor [TNF] receptor family
• CD antigen
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/O14798.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8794
• OMIM: https://mirror.omim.org/entry/603613
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8794